D-1 and D-2 Agonists in Parkinson's Disease
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منابع مشابه
BUPROPION-INDUCE D CLIMBING THROU GH D -1 AND D-2 DOPAMINE RECEPTOR ACTIVATION
Intraperitoneal (IP) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. The climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist SCH 233<)0 or the 0-2 antagonist sulpiride. The α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-ad...
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In primates, CB(1) cannabinoid receptor agonists produce sedation and psychomotor slowing, in contrast to behavioral stimulation produced by high doses of dopamine receptor agonists. To investigate whether dopamine agonists attenuate the sedative effects of a cannabinoid agonist in monkeys, we compared the effects of D(1) or D(2) dopamine receptor agonists on spontaneous behavior in three to si...
متن کاملbupropion-induce d climbing throu gh d -1 and d-2 dopamine receptor activation
intraperitoneal (ip) injection of bupropion (3,6, amine (4,16 mg kg•') induced dose-dependent climbing in mice. the climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist sch 233<)0 or the 0-2 antagonist sulpiride. the α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-adre...
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The reinforcing effects of D(1-like) and D(2-like) agonists, and their capacity to modify cocaine self-administration, were compared in rats with extensive cocaine self-administration experience. Cocaine (0.01-1.0 mg i.v.) dose-dependently maintained responding under a fixed ratio (FR) 5 schedule of reinforcement, and an inverted U-shaped function characterized the relationship between unit dos...
متن کاملD 1 - and D 2 - Dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding
Behavioral responses to o, and Drdopamine agonists are enhanced when these agonists are administered systemically to 6hydroxydopamine (6-0HDA)-lesioned rats. In the present investigation, microinjectiOn of SKF-38393, a 0,-dopamine agonist, into the nucleus accumbens of adult rats lesioned as neonates with 6-0HDA produced a dose-related increase in locomotor activity that was enhanced markedly c...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1987
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100037938